Epitranscriptomic RNA editing resolves Mus81 DNA repair tradeoffs in heat tolerance and meiosis - PubMed
8 hours ago
- #RNA editing
- #fungal pathogen
- #DNA repair
- FgMus81 has dosage-dependent functions: low levels support meiosis, high levels aid heat-stress survival.
- An A-to-I RNA editing event (N420D) in FgMus81 tunes its abundance to meet meiotic demands without affecting stress resilience.
- The post-editing isoform impairs mitotic recombination but supports meiotic interhomolog crossovers.
- This RNA editing is conserved across Sordariomycetes, indicating evolutionary selection for stage-specific control.
- Epitranscriptomic RNA editing resolves a trade-off between heat tolerance and meiosis in Fusarium graminearum.