Glymphatic influx is negatively correlated with cerebral blood volume in male mice - PubMed
8 hours ago
- #Neuroimaging
- #Glymphatic System
- #Cerebral Blood Volume
- Glymphatic influx varies with different anesthetic and awake states, increasing under certain conditions (isoflurane/dexmedetomidine, dexmedetomidine, caffeine, ketamine/xylazine) and decreasing with isoflurane compared to awake.
- Across all tested conditions, glymphatic influx shows a negative correlation with cerebral blood volume (CBV) and a positive correlation with extra-ventricular cerebrospinal fluid volume.
- The study suggests that CBV may act as a tonic vascular component influencing glymphatic function independently of consciousness, complementing dynamic drivers like vasomotion.
- Modulating CBV is proposed as a potential therapeutic strategy to enhance waste clearance in neurodegenerative diseases involving protein aggregation.