Brain organoids as precision models for neurodegenerative diseases: from disease modeling to drug discovery - PubMed
5 days ago
- #brain organoids
- #neurodegenerative diseases
- #drug discovery
- Brain organoids derived from iPSCs offer a 3D model that mimics human brain development and neurodegenerative disease pathology.
- These organoids overcome limitations of traditional 2D cell cultures and animal models by better recapitulating human-specific neuropathology.
- Integration with CRISPR-Cas9 genome editing and multi-omics profiling enhances their use in disease mechanism studies and drug discovery.
- Current challenges include insufficient maturation, lack of vascularization, immune components, and batch variability.
- Advances in bioengineering, microfluidics, and AI-driven data analysis are improving the translational potential of brain organoids.
- Brain organoids are pivotal for developing precision medicine approaches and new therapies for neurodegenerative diseases.