TDP-43 pathology triggers neuroinflammation and cognitive impairment by inducing microglial necroptosis - PubMed
2 days ago
- #Necroptosis
- #TDP-43
- #Neuroinflammation
- TDP-43 pathology is linked to neurodegenerative diseases like ALS, FTD, and AD.
- Cytoplasmic mis-localization of TDP-43 triggers neuroinflammation and microglial necroptosis via RIPK3.
- Pharmacological inhibition of RIPK3 with GSK872 reduces neuroinflammation and cognitive deficits in mice.
- Nuclear depletion of TDP-43 leads to RIPK3 upregulation, activating necroptosis.
- Necroptosis is identified as a therapeutic target for TDP-43-related disorders.