Assessing the therapeutic effects of DPP4 Inhibitors on TGF-β2-induced Lens Opacity - PubMed
7 hours ago
- #DPP4 inhibitors
- #TGF-β signaling
- #Posterior capsular opacification
- Posterior capsular opacification (PCO) is a common complication after cataract surgery, caused by EMT of lens epithelial cells (LECs).
- DPP4 inhibitors (Sitagliptin, Saxagliptin, Vildagliptin) were tested for their ability to mitigate TGF-β2-induced EMT in LECs.
- DPP4 inhibitors reduced fibrotic changes in LECs by blocking Smad2 phosphorylation, as shown by decreased EMT marker expression.
- Vildagliptin-treated lens explant cultures showed reduced TGF-β2-induced lens opacity.
- DPP4 inhibitors, especially Vildagliptin, may offer a non-invasive pharmacological approach to preventing PCO by targeting TGF-β signaling.