Human narcolepsy is linked to degeneration of both locus coeruleus and hypocretin neurons - PubMed
2 days ago
- #narcolepsy
- #locus coeruleus
- #neurodegeneration
- Human narcolepsy with cataplexy is associated with a 46% loss of norepinephrine neurons in the locus coeruleus.
- Hypocretin neuron degeneration in the hypothalamus is also linked to narcolepsy, with microglial involvement in both neuronal groups.
- The study analyzed 11 brains, revealing an 18% increase in size of remaining locus coeruleus neurons in narcolepsy patients.