Single-nucleus multi-omics analysis of mouse small-intestinal Lgr5+ cell populations reveals Foxa3-induced Paneth cell-lineage differentiation - PubMed
9 hours ago
- #Paneth cell differentiation
- #PPAR signaling
- #Lgr5+ stem cells
- Single-nucleus multi-omics analysis of mouse small-intestinal Lgr5+ stem cells reveals cellular heterogeneity.
- Identified 6 subsets of Lgr5+ cell populations with distinct gene expression and chromatin structure.
- Early fate-determining processes diverge absorptive and secretory lineages within Lgr5+ cells.
- Foxa3 identified as a key transcription factor regulating intestinal secretory precursor differentiation.
- Foxa3 knockdown disrupts Paneth cell differentiation via modulation of PPAR signaling pathway.
- Foxa3 predominantly drives Paneth cell differentiation by regulating PPAR pathway core genes.
- Provides a reference map for understanding intestinal epithelial development and related diseases.