Vitamin D binding protein induces skeletal muscle atrophy and contributes to cancer-associated muscle wasting independently of vitamin D status in preclinical models - PubMed
3 hours ago
- #vitamin D binding protein
- #muscle atrophy
- #cancer cachexia
- Vitamin D binding protein (VDBP) induces skeletal muscle atrophy and contributes to cancer-associated muscle wasting independently of vitamin D.
- VDBP causes atrophy in C2C12 myotubes by perturbing intracellular actin dynamics and mitochondrial fragmentation.
- In Gc-knockout mice, ectopic VDBP introduction leads to muscle atrophy and decreased strength.
- VDBP contributes to muscle wasting in Lewis lung carcinoma-bearing male mice, suggesting a role in cancer-associated cachexia.
- The study identifies VDBP as a pro-atrophic hormone with potential implications for treating muscle wasting conditions.