Obesity drugs quiet 'food noise' in the brain
5 days ago
- #GLP-1
- #obesity
- #neuroscience
- Obesity drug tirzepatide (Mounjaro/Zepbound) may suppress brain activity linked to food cravings.
- Study observed reduced 'food noise'—intrusive thoughts about eating—in a person with severe obesity after taking tirzepatide.
- Researchers initially aimed to test deep brain stimulation for compulsive eating but found unexpected effects of tirzepatide.
- Electrodes implanted in the nucleus accumbens recorded surges in low-frequency brain activity during food cravings.
- A participant on tirzepatide showed suppressed food-related brain activity, suggesting the drug's potential neural impact.
- Findings highlight the role of GLP-1 receptors in modulating reward-related brain activity.