WFDC21P is essential for G3BP1-mediated RIG-I activation and antitumor immunity in triple-negative breast cancer - PubMed
7 hours ago
- #antitumor immunity
- #WFDC21P
- #triple-negative breast cancer
- WFDC21P is crucial for activating the RIG-I pathway via G3BP1 in triple-negative breast cancer, enhancing antitumor immunity.
- It facilitates the formation of G3BP1-RIG-I-dsRNA condensates through phase separation, boosting RIG-I activation.
- Low WFDC21P levels in TNBC correlate with reduced CD8+ T cell infiltration and poorer patient outcomes.
- Knockdown of WFDC21P impairs RIG-I activation, decreases IFN-stimulated gene expression, including MHC-I and PD-L1.
- In models, WFDC21P expression suppresses tumor growth, enhances CD8+ T cell function, and improves immune checkpoint blockade response.