ESKD, Major Cardiovascular Events, and Death Associated With Systemic Inflammation - PubMed
2 hours ago
- #Systemic Inflammation
- #Cardiovascular Events
- #Chronic Kidney Disease
- Systemic inflammation may influence chronic kidney disease (CKD) progression and major cardiovascular events (MACE).
- Study compared outcomes in CKD patients with high sensitivity C-reactive protein (hsCRP) ≥ 2 mg/l vs. < 2 mg/l.
- 163,854 CKD patients (eGFR < 60 ml/min or albumin-to-creatinine ratio > 200 mg/g) were analyzed.
- After matching, 27,580 patients in each group showed hsCRP ≥ 2 mg/l linked to higher MACE and death risks.
- No significant association found between hsCRP ≥ 2 mg/l and end-stage kidney disease (ESKD) in general CKD patients.
- Diabetic CKD patients (21,700) with hsCRP ≥ 2 mg/l had higher risks of MACE, death, and ESKD.
- Conclusion: Systemic inflammation independently increases MACE and death risks in CKD, and ESKD risk in diabetic CKD patients.