A20 enhances the migration and metastasis of gastric cancer cells by promoting occludin degradation - PubMed
3 hours ago
- #gastric cancer
- #A20 TNFAIP3
- #metastasis
- A20 (TNFAIP3) enhances migration and metastasis in gastric cancer cells.
- Overexpression of A20 is linked to increased tumor aggressiveness and metastasis in gastric cancer patients.
- A20 promotes epithelial-mesenchymal transition and reduces the tight junction protein occludin.
- Mechanistically, A20 induces occludin endocytosis and lysosomal degradation via its OTU domain.
- A20 interacts with RhoA, stabilizing it and sustaining ROCK2 phosphorylation, which contributes to occludin degradation.
- The OTU domain of A20 is necessary for its interaction with RhoA.
- The study suggests A20 as a potential therapeutic target to inhibit gastric cancer metastasis.