Mitochondrial DNA as a driver of inflammation via the cGAS-STING pathway - PubMed
10 hours ago
- #mitochondrial DNA
- #inflammation
- #cGAS-STING pathway
- Mitochondrial DNA (mtDNA) acts as a damage-associated molecular pattern (DAMP) that translocates to the cytoplasm and activates the cGAS-STING pathway.
- Activation of the cGAS-STING pathway leads to the production of type I interferons and senescence-associated secretory phenotype (SASP), linking mtDNA to inflammation and cellular senescence.
- The mtDNA-cGAS-STING axis is implicated in various inflammation-related pathologies, including ocular, neurodegenerative, pulmonary, cardiovascular, and oral diseases.
- Targeting the mtDNA-cGAS-STING axis shows promise in preclinical models but faces challenges in specificity, delivery, and side effects for clinical translation.
- Further mechanistic understanding of this axis could provide innovative therapeutic strategies for managing inflammation and aging-associated diseases.