Pathophysiology of colitis-associated colorectal cancer - PubMed
3 hours ago
- #colorectal-cancer
- #tumor-microenvironment
- #inflammatory-bowel-disease
- Colitis-associated colorectal cancer (caCRC) develops in patients with inflammatory bowel disease (IBD), with rising global IBD prevalence increasing risk.
- The pathophysiology of caCRC differs from sporadic CRC, involving tumor epithelium, stromal cells in the tumor microenvironment, immune cells, and gut microbiome signals.
- Research highlights the role of stromal and immune cells in tumor control or promotion, and the influence of the microbiome on caCRC development.
- The review discusses the heterogeneity of caCRC and potential therapeutic implications for personalized medicine targeting this cancer subtype.