Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis - PubMed
4 hours ago
- #PCK1
- #metabolism
- #liver fibrosis
- PCK1 reduction in hepatic stellate cells (HSCs) correlates with liver fibrosis severity.
- Silencing PCK1 activates HSCs and increases fibrotic markers, while PCK1 overexpression inhibits HSC activation.
- Activated HSCs exhibit elevated glycolysis and TCA cycle activity; PCK1 overexpression reduces acetyl-CoA and TCA intermediates.
- HSC-specific PCK1 loss in mice accelerates diet-induced liver fibrosis and causes spontaneous fibrosis on a normal diet.
- PCK1 disruption enhances glycolysis and HSC activation, promoting liver fibrosis.