Pretherapeutic prognostic factors for survival under chemoimmunotherapy/immunotherapy of advanced NSCLC patients - PubMed
4 hours ago
- #immunotherapy
- #NSCLC
- #prognostic factors
- Study focuses on identifying pretherapeutic prognostic factors for survival in advanced NSCLC patients undergoing chemoimmunotherapy or immunotherapy.
- Key factors analyzed include ECOG status, PD-L1 TPS, serum LDH, serum CRP, and KEAP-1 mutation.
- Retrospective analysis of 120 patients compared 'super responders' (survival >24 months) vs. primary progressors (PFS <10 months).
- Five factors showed significant impact on overall survival in both univariate and multivariate analyses.
- Confirmed prognostic factors: initial ECOG of zero, non-elevated LDH and CRP, PD-L1 positivity, and absence of KEAP1 mutation.
- Findings aim to help estimate early treatment failure in aggressive lung cancer cases.
- Future plans include prospective validation in a larger, more diverse patient population.