Obacunone Promotes Functional Recovery After Spinal Cord Injury by Attenuating Neuroinflammation by Targeting the TLR4/MyD88/p38 MAPK Pathway - PubMed
3 hours ago
- #spinal cord injury
- #TLR4 pathway
- #neuroinflammation
- Obacunone (Oba) promotes functional recovery after spinal cord injury (SCI) by reducing neuroinflammation and apoptosis.
- Oba targets the TLR4/MyD88/p38 MAPK pathway to exert its anti-inflammatory effects.
- In vivo studies show Oba improves motor function, neural repair, and reduces inflammation and apoptosis in SCI mice.
- In vitro, Oba suppresses pro-inflammatory cytokines in LPS-induced BV-2 microglial cells and protects neurons from inflammatory apoptosis.
- Oba's neuroprotective effects suggest its potential as a therapeutic agent for SCI.