Integrative Proteomic Profiling of Blood Pressure and Hypertension - PubMed
4 hours ago
- #proteomics
- #hypertension
- #biomarkers
- Large-scale proteomic analysis identified associations between plasma proteins and blood pressure traits, including systolic and diastolic blood pressure and hypertension prevalence.
- Studies involving UK Biobank and Framingham Heart Study participants validated numerous proteins linked to hypertension, with some associated with new-onset cases.
- Mendelian randomization suggested causal relationships for proteins with blood pressure traits, implicating processes like inflammation and vascular remodeling.
- NHERF2 protein showed potential causal links to blood pressure traits and hypertension, indicating it as a therapeutic target.
- Blood pressure-related proteins are enriched for associations with cardiovascular, liver, and kidney diseases, highlighting systemic health implications.