Orai1 Facilitates Angiogenesis After Myocardial Infarction Through Notch1 Signaling Pathway - PubMed
2 hours ago
- #Calcium Signaling
- #Angiogenesis
- #Myocardial Infarction
- Orai1-dependent store-operated calcium entry supports angiogenesis after myocardial infarction (MI).
- Serum from MI patients upregulates VEGF, Notch, and Ca2+ signaling, increasing Orai1 expression and activity.
- Orai1 inhibition impairs angiogenesis in zebrafish embryos, and its upregulation is confirmed in tip cells and proliferating endothelial cells.
- Orai1 silencing disrupts VEGF and Notch1-related proteins, and IL-17A mimics MI serum effects on Orai1.
- Orai1 is a potential therapeutic target for cardiac repair post-MI.