DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses - PubMed
4 hours ago
- #STING signaling
- #DNA-PKcs
- #cyclic dinucleotides
- DNA-PKcs interacts with cyclic dinucleotides (CDNs) and inhibits type I interferon responses.
- DNA-PKcs directly binds to 2'3'-cGAMP CDN via its kinase domain, modulating STING activation.
- DNA-PKcs also affects bacterial 3'3'-cGAMP and pharmacological STING agonists, influencing antiviral responses.
- STING agonism is explored as a therapeutic strategy for immunosuppressive pathologies.
- DNA-PKcs serves as a CDN signaling modulator, and CDNs inhibit DNA-PKcs kinase activity.
- Findings have implications for developing STING-targeting therapeutics.