Free water in the hippocampal cingulum as a Radiomic biomarker for Identifying inflammatory neuropsychiatric Lupus: A cross-sectional case-control study - PubMed
3 hours ago
- #Machine Learning
- #Neuroimaging
- #Autoimmune Disease
- The study investigates free water (FW)-corrected diffusion model parameters to identify white matter microstructural changes in neuropsychiatric systemic lupus erythematosus (NPSLE).
- Participants included 33 inflammatory NPSLE patients, 24 ischemic NPSLE patients, and 33 non-NPSLE patients, with diffusion MRI and tract-based spatial statistics (TBSS) used for analysis.
- Significant FW elevation was found in the bilateral hippocampal cingulum bundles of inflammatory NPSLE patients compared to non-NPSLE, suggesting neuroinflammation as a biomarker.
- Machine learning models combining FW values with clinical indicators achieved high accuracy (up to 92.86% in external validation) for distinguishing inflammatory NPSLE.