Climbing fibres recruit disinhibition to enhance Purkinje cell calcium signals - PubMed
3 hours ago
- #cerebellum
- #plasticity
- #neuroscience
- Climbing fibres (CFs) enhance Purkinje cell (PC) calcium signals by recruiting disinhibition.
- CFs activate molecular layer interneurons (MLIs), which can inhibit PCs but also disinhibit them via MLI subtypes (MLI1s and MLI2s).
- MLI1s inhibit PCs and suppress plasticity, while MLI2s inhibit MLI1s, disinhibiting PCs and promoting plasticity.
- CFs preferentially excite MLI2s through glutamate spillover, leading to disinhibition of PCs.
- In vivo recordings show spontaneous CF activity excites MLI2s, inhibits MLI1s, and disinhibits PCs.
- Learning-related sensory stimulation shifts the balance towards MLI1 suppression, enhancing PC dendritic calcium signals for plasticity.
- CF synchrony is highly effective at inducing cerebellar learning by enhancing PC calcium signals via disinhibition.