Mas-Related G Protein-Coupled Receptor Member D Sustains Hypertension - PubMed
19 hours ago
- #hypertension
- #MrgD receptor
- #vascular remodeling
- MrgD is upregulated in arterial tissues of hypertensive patients and animal models.
- MrgD overexpression elevates blood pressure and promotes vascular remodeling, while knockdown or knockout reverses these effects.
- Mechanistically, MrgD drives vascular remodeling via the Cav1.2-CaMKIIγ signaling axis in vascular smooth muscle cells.
- Ang II enhances the interaction among MrgD, CaMKIIγ, and Cav1.2 to promote VSMC phenotypic switch.
- Risperidone was identified as a MrgD inhibitor that attenuates hypertension and vascular remodeling.