Dual Oscillatory Signatures in Pallidal Circuits Underlie Symptom Complexity in Huntington's Disease Patients - PubMed
3 hours ago
- #Deep Brain Stimulation
- #Huntington's Disease
- #Neural Oscillations
- Huntington's disease (HD) presents both hyperkinetic and hypokinetic symptoms, challenging clinical management.
- Theta power (2-8 Hz) in pallidal circuits increased during hyperkinetic states, while high beta power (20-30 Hz) rose during hypokinetic states, correlating with symptom severity.
- These oscillatory patterns were not affected by voluntary movement and differed from those in Parkinson's disease and dystonia.
- Theta coherence linked to indirect pathway structural connectivity, and high beta power associated with direct pathway functional connectivity, reflecting dual circuit pathology in HD.
- Theta oscillations localized to the posterior globus pallidus, projecting to motor cortical areas, providing biomarkers for disease monitoring and deep brain stimulation optimization.