Transcatheter Intra-Arterial Delivery of a Platelet-Derived Extracellular Vesicle-Enriched Preparation for Attenuating Skeletal Muscle Ischaemia-Reperfusion Injury in a Rodent Forelimb Model - PubMed
3 hours ago
- #ischemia-reperfusion-injury
- #limb-infusion
- #extracellular-vesicles
- Platelet-derived extracellular vesicles (EVs) show anti-inflammatory and antioxidant properties, making them promising for treating skeletal muscle ischemia-reperfusion injury (IRI).
- A catheter-directed regional intra-arterial limb infusion (RLI) was developed to deliver platelet-derived EVs selectively to limb muscles, simulating clinical conditions like limb revascularization or transplantation.
- The study demonstrated robust retention of EVs in skeletal muscles during early reperfusion, reducing metabolic issues, proinflammatory cytokine responses, and myofiber injury without adverse effects on serum chemistry.
- This approach offers a novel therapeutic strategy for mitigating limb IRI and enables targeted delivery of nanocarriers for other applications in isolated limb tissues.