Defining subcellular synovial responses in TMJ osteoarthritis onset via mechanical stress and articular disk derangement models - PubMed
7 hours ago
- #synovial response
- #TMJ-OA
- #transcriptomics
- Study focuses on subcellular synovial responses in TMJ osteoarthritis (TMJ-OA) onset.
- TMJ-OA is influenced by adaptive, inflammatory, and mechanical stressors.
- Molecular alterations in the synovium were examined using transcriptomic approaches.
- Techniques included subcellular spatial transcriptomics and single-cell RNA sequencing.
- Synovial changes linked to adipogenesis, fibrosis, and macrophage activation were identified.
- Cell type-specific catabolic changes suggest contributions to TMJ-OA onset.
- Findings provide a resource for investigating TMJ disorder molecular pathology.
- Potential implications for developing targeted therapeutic strategies.