KDM3A catalyses the oxidation of acetyl-lysine to hydroxyacetyl-lysine on histone H3K9 - PubMed
3 hours ago
- #histone modification
- #KDM3A
- #hydroxyacetyl-lysine
- KDM3A, a JmjC histone demethylase, oxidizes acetyl-lysine on histone H3K9 to hydroxyacetyl-lysine (H3K9acOH).
- This O2-dependent reaction reveals an unexpected link between histone lysine acetylation and JmjC catalysis.
- The hydroxyacetyl-lysine modification is recognized by proteins binding H3K9ac, including histone deacetylases and AF9.
- Cellular relevance of hydroxyacetyl-lysine is supported by selective antibodies and mass spectrometry.