Mitochondria transplantation reduces intraocular pressure by improving mitochondrial function and remodeling trabecular meshwork - PubMed
4 days ago
- #Mitochondrial transplantation
- #Intraocular pressure
- #Glaucoma
- Mitochondrial transplantation is a promising therapy for diseases with mitochondrial dysfunction, including primary open-angle glaucoma (POAG).
- The study demonstrated that TM cells actively take up exogenous mitochondria, which helps reduce oxidative stress and improve cell viability.
- Exogenous mitochondria suppress excessive mitophagy, restoring autophagic homeostasis and increasing cell survival.
- In vivo studies showed preferential accumulation of transplanted mitochondria in the trabecular meshwork (TM) region, leading to sustained intraocular pressure (IOP) reduction.
- A single intracameral injection of mitochondria was more effective than first-line clinical hypotensive agents like Timolol maleate and Latanoprost eye drops.
- This research provides the first systematic evidence supporting mitochondrial transplantation as an effective anti-glaucoma therapy.