Unraveling the complexity of the histone code: implications for gene regulation and disease - PubMed
6 hours ago
- #disease mechanisms
- #gene regulation
- #epigenetics
- Histone post-translational modifications (PTMs) epigenetically regulate gene expression by altering nucleosome structure and DNA accessibility.
- Combinatorial histone codes are formed by unique patterns of modifications on canonical and variant histones, with interplay increasing complexity and enabling context-dependent outcomes.
- The histone code is dynamic, fluctuating with environmental cues, metabolic state, and cell-cycle progression.
- Dysregulation of histone modifications contributes to diseases, and emerging technologies offer new biological insights and therapeutic opportunities.