Single-cell proteomics reveal lesion-specific aberrant T cells and immunological profiles in Mycosis Fungoides - PubMed
4 hours ago
- #Mycosis Fungoides
- #Tumor microenvironment
- #Single-cell proteomics
- Single-cell proteomics used to study Mycosis Fungoides (MF), a cutaneous T cell lymphoma.
- Aberrant CD4+CD7-CD26-CCR4hi T cells with high PD-1, PD-L1, and OX-40 levels enriched in tumor lesions but absent in patches.
- PD-L1+ T cells showed central/effector memory phenotype, while PD-1+ T cells had a terminal effector phenotype.
- Tumor microenvironment (TME) in MF showed increased PD-L1+ memory B cells, regulatory T cells, and PD-1+ CD4+/CD8+ T cells.
- Patches lacked innate lymphoid cells, memory B cells, and naïve/CM CD8+ T cells.
- Large Cell Transformation linked to higher frequencies of naïve B cells, PD-1+ monocytes, and PD-1+ CD8+ CM/EM T cells.
- High PD-L1+ memory B cells and PD-1+ DCs correlated with shorter progression-free survival.
- Normal PD-1+ transitional monocytes associated with longer overall survival.
- Lesion-specific aberrant T cells and TME remodeling may influence MF severity and immunotherapy outcomes.