Nasal Airway Transcriptome Reflects Selected Asthma-Associated Gene Signatures in the Lower Airways - PubMed
a day ago
- #non-invasive
- #asthma
- #transcriptomics
- Transcriptomic analysis of bronchial brushes reveals asthma-associated gene signatures but is limited by invasiveness.
- The study evaluated if nasal brushes reflect asthma-associated transcriptomic changes in lower airways based on the 'united airways' hypothesis.
- 26 asthma patients and 28 healthy controls were included in the ARMS study, with nasal and bronchial brushes collected for RNA sequencing.
- 51 asthma-associated genes were identified in lower airways, with 40 up-regulated and 11 down-regulated in asthma compared to healthy controls.
- Seven up-regulated genes (CLCA1, FETUB, CST1, NTRK2, CDH26, TPSAB1, DHX35) were also up-regulated in nasal brushes and validated in the ATLANTIS study.
- Two gene modules consistently elevated in asthma across bronchial and nasal brushes were identified: IL-13 related inflammation and mast cell activity.
- The shared gene signatures reflect two components of type 2 inflammation, offering a non-invasive tool to identify asthma endotypes.