We are all mosaics: genetic diversity found between cells in a single person
14 days ago
- #DNA-sequencing
- #mosaicism
- #genomics
- Researchers sequenced whole genomes of over 100 individual cells from a 74-year-old man, revealing significant genetic variations.
- Findings showed extra chromosome arms, missing chunks, and DNA alterations, deletions, or duplications in cells.
- The study is part of a $140-million consortium aiming to catalog mutations in cells from 150 donors across 19 body sites.
- Mosaicism, genetic variation between cells of a single individual, impacts health and diseases like cancer.
- Improved DNA-sequencing technologies highlight mosaicism's prevalence and health effects, such as cancer and cardiovascular risks.
- Single-cell genome analysis is advancing but faces challenges due to limited DNA copies per cell.