Obesity and asthma: obesity causes and aggravates asthma across the entire type-2 inflammation spectrum - PubMed
2 days ago
- #inflammation
- #obesity
- #asthma
- Obesity affects over 650 million adults globally, with rising prevalence.
- Individuals with obesity have a 30-50% higher risk of developing asthma.
- Obesity is highly prevalent among people with established asthma, with up to 70% of patients being overweight or obese.
- Obesity is linked to poorer asthma control and higher exacerbation risks.
- Obesity-associated asthma is heterogeneous, not restricted to a single phenotype.
- Excess adiposity influences asthma via multiple mechanisms, including dysregulated adipokine signaling and systemic inflammation.
- Weight reduction improves asthma symptoms, lung function, and exacerbation risk across asthma types.
- Anti-T2 biologics reduce exacerbations in obese patients similarly to lean counterparts, though symptom and lung function improvements vary.
- Future research should focus on GLP-1 and dual GLP-1/GIP-agonist therapies for asthma and obesity.