Gut-microbiota-derived 3-indoleacrylic acid alleviates neonatal necrotizing enterocolitis by inhibiting epithelial necroptosis - PubMed
5 hours ago
- #necrotizing enterocolitis
- #necroptosis
- #3-indoleacrylic acid
- Gut-microbiota-derived 3-indoleacrylic acid (IA) is reduced in neonatal necrotizing enterocolitis (NEC) patients and models, and its supplementation alleviates intestinal inflammation and tissue damage.
- IA inhibits STAT1-driven necroptosis in intestinal epithelial cells via the AhR-SOCS5 axis, and this protection is lost when AhR is inhibited or knocked out.
- Oral administration of Bifidobacterium longum subsp. infantis containing the IA-producing fldI gene prevents NEC in mice, suggesting a potential therapeutic strategy.