Human antibody targeting Crimean-Congo hemorrhagic fever virus glycoprotein 38 protects mice against heterologous virus challenge - PubMed
4 hours ago
- #CCHFV
- #Monoclonal Antibodies
- #Viral Glycoproteins
- A panel of monoclonal antibodies (mAbs) was isolated from a human immune donor after natural nosocomial infection with Crimean-Congo hemorrhagic fever virus (CCHFV).
- The antibodies target two glycoproteins: Gc (fusion protein) and GP38, with genetic diversity observed in B cell responses to both within the donor.
- Neutralization activity was not linked to protection; Gc-specific antibodies showed weak neutralization and did not protect against heterologous challenge.
- GP38-specific antibodies, targeting two dominant antigenic sites, did not neutralize but one mediated protection against heterologous challenge in mice via complement-mediated activity.
- The findings support developing CCHFV countermeasures that induce protective responses against GP38.