A Small-Molecule SLD1121 Activates Wnt/β-Catenin Signaling and Promotes Hair Growth via Targeting the Wnt Coreceptor LRP6 - PubMed
3 hours ago
- #Hair growth
- #Wnt signaling
- #Alopecia treatment
- SLD1121 is a small molecule that activates the Wnt/β-catenin signaling pathway by targeting the Wnt coreceptor LRP6.
- SLD1121 interacts with the intracellular domain of LRP6, stabilizes it, and promotes its nuclear translocation.
- The compound enhances the association of LRP6 with β-catenin, TCF4, or LEF1 in the nucleus, leading to the expression of Wnt regulatory and stemness-associated genes.
- In a mouse hair regeneration model, SLD1121 induced the transition of hair follicles from the telogen to anagen phase, promoting hair growth.
- SLD1121 has potential as a therapeutic agent for alopecia by targeting LRP6 and activating Wnt/β-catenin signaling.