Epigenetic regulation in a high-sugar environment (Review) - PubMed
5 hours ago
- #hyperglycemia
- #diabetes
- #epigenetics
- Epigenetic regulation is central to 'metabolic memory' in diabetes and its complications.
- High glucose alters DNA methylation in genes like PDX1 and CXCR4 in key cells (e.g., pancreatic β-cells, hepatocytes).
- High glucose modulates histone modifications, including H3K18la, activating pathogenic gene transcription.
- Non-coding RNA networks (e.g., MALAT1, microRNA 21) are disrupted, affecting pathways like PI3K/Akt and TGF-β.
- Epigenetic changes are tissue-specific, influencing complications like diabetic nephropathy and cardiovascular disease.
- Targeting epigenetic enzymes (e.g., DNA methyltransferases) offers potential therapeutic strategies.