Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum - PubMed
5 hours ago
- #demyelination
- #senolytics
- #multiple sclerosis
- Senolytic treatment with dasatinib and quercetin (D+Q) causes demyelination in the corpus callosum of mice.
- D+Q treatment leads to oligodendrocyte dysfunction without causing cell death.
- In vitro studies show D+Q reduces myelin basic protein and morphological complexity in oligodendrocytes.
- RNA sequencing reveals D+Q induces endoplasmic reticulum stress and the unfolded protein response in oligodendrocytes.
- D+Q-treated oligodendrocytes resemble those found in multiple sclerosis (MS) lesions, suggesting a model for studying MS pathology.