S-nitrosoglutathione reductase GSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1 - PubMed
4 hours ago
- #age-related obesity
- #Beclin-1
- #GSNOR
- GSNOR (S-nitrosoglutathione reductase) increases in adipose tissue during middle-age in both mice and humans.
- GSNOR knockout protects against age-related weight gain and improves metabolism, while its overexpression promotes obesity and metabolic decline.
- Aged GSNOR knockout mice maintain higher mitochondrial content and more beige adipocytes, whereas GSNOR overexpression leads to adipose tissue whitening.
- GSNOR denitrosates Beclin-1 at cysteine 351, and mutation at this site (Beclin-1C351A) enhances autophagy by increasing Beclin-1 and ATG14 interaction.
- This mechanism accelerates the conversion of beige to white adipocytes, contributing to age-related obesity.
- The study suggests GSNOR as a potential therapeutic target for age-related obesity.