A Decision-Support System to Personalize Antidepressant Treatment in Major Depressive Disorder: A Randomized Clinical Trial - PubMed
3 hours ago
- #Clinical Trial
- #Antidepressant Treatment
- #Major Depressive Disorder
- A randomized clinical trial evaluated a web-based decision-support system (PETRUSHKA tool) for personalizing antidepressant treatment in major depressive disorder.
- The study involved 540 participants across 47 sites in Brazil, Canada, and the UK, comparing the PETRUSHKA tool to usual care.
- Primary outcome: At 8 weeks, 17% in the PETRUSHKA group discontinued antidepressants vs. 27% in usual care (adjusted relative risk 0.62, P = .007).
- Secondary outcomes: PETRUSHKA group showed lower discontinuation due to adverse events (9% vs. 16%, P = .04) and better symptom improvement at 24 weeks.
- Depressive symptoms (PHQ-9) at 24 weeks: PETRUSHKA mean score 7.1 vs. usual care 9.2 (P < .001).
- Anxiety symptoms (GAD-7) at 24 weeks: PETRUSHKA mean score 4.6 vs. usual care 5.8 (P = .002).
- Limitations include lack of double-blind design and significant missing data, affecting result validity.