Oliceridine versus Sufentanil for Postoperative Recovery and Opioid-Related Adverse Events in Patients Undergoing Thoracoscopic Lobectomy: A Randomized Double-Blind Controlled Trial - PubMed
6 hours ago
- #Opioid-Related Adverse Events
- #Thoracoscopic Surgery
- #Oliceridine
- Oliceridine and sufentanil were compared for perioperative use in thoracoscopic lobectomy patients in a randomized double-blind trial.
- The study found oliceridine significantly reduced postoperative nausea/vomiting (PONV) and respiratory depression compared to sufentanil.
- Oliceridine showed higher Quality of Recovery-15 (QoR-15) scores at 24 and 48 hours post-surgery.
- No significant differences were observed in hemodynamic stability, pain scores (NRS), or sedation (Ramsay) between the two groups.
- Researchers concluded oliceridine offers safe, effective analgesia with fewer opioid-related adverse events and better recovery.