Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle - PubMed
3 hours ago
- #TCA cycle
- #citrate metabolism
- #ACO2
- Citrate clearance is a key function of aconitase 2 (ACO2) in the TCA cycle.
- Increased citrate production raises TCA cycle activity and dependence on ACO2.
- Disrupting citrate catabolism activates the integrated stress response and harms cell fitness.
- Preventing citrate production or promoting mitochondrial citrate efflux reverses these effects.
- ACO2 deficiency leads to citrate accumulation and kidney tubular degeneration in vivo.
- Intracellular citrate accumulation is a metabolic liability.
- The study highlights the importance of citrate clearance by ACO2 in the TCA cycle.