Multimodal framework for the joint analysis of single-cell RNA and T cell receptor sequencing data predicts T cell response to cancer immunotherapy - PubMed
7 hours ago
- #immunotherapy
- #single-cell sequencing
- #T cell receptor
- TRIM is a multimodal framework integrating single-cell RNA and TCR sequencing data to predict T cell response to cancer immunotherapy.
- The model learns shared representations from patient, tissue source, and treatment timepoint data.
- Applied to datasets from head and neck squamous cell carcinoma, colorectal cancer, and a pan-cancer dataset, TRIM accurately predicted T cell clonal expansion and transcriptional status.
- The study demonstrates TRIM's utility in modeling multimodal T cell data and predicting treatment response and disease progression.
- Authors disclose various competing interests, including advisory roles and funding from biotech and pharmaceutical companies unrelated to this study.