7-days versus 14-days antibiotic therapy in uncomplicated culture proven neonatal sepsis: a randomized control assessor-blinded trial - PubMed
4 hours ago
- #Antibiotic stewardship
- #Randomized control trial
- #Neonatal sepsis
- A 7-day antibiotic therapy is non-inferior to 14-day therapy for uncomplicated neonatal sepsis, with no fatalities or definitive relapses reported.
- The randomized control trial involved 140 neonates with culture-positive sepsis, divided into 7-day and 14-day groups, showing low relapse incidence in both.
- The 7-day group had a shorter hospital stay and required less respiratory support compared to the 14-day group.
- Klebsiella pneumoniae was the most common pathogen identified in the study population.
- The trial supports antibiotic stewardship by reducing treatment duration, potentially minimizing risks associated with prolonged antibiotic use in neonates.