Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model - Pub
4 hours ago
- #neurodegeneration
- #chronic cerebral hypoperfusion
- #glymphatic system
- Chronic cerebral hypoperfusion (CCH) exacerbates amyloid and tau pathology by impairing glymphatic transport.
- CCH reduces AQP4 polarization, leading to accumulation of Aβ and p-tau217.
- Single-cell RNA sequencing identified downregulation of VEGF, Rho GTPase, and integrin-actin signaling pathways.
- Restoring vascular tone with adrenergic receptor blocker improved glymphatic clearance and cognitive function.
- The study establishes a link between vascular dysfunction and neurodegeneration in cognitive impairment.