Single cell and multi-omics analysis reveal senescence-related molecular subtypes and a prognostic signature in clear cell renal cell carcinoma - PubMed
4 hours ago
- #Senescence
- #Prognosis
- #ccRCC
- Clear cell renal cell carcinoma (ccRCC) is highly heterogeneous and has a poor prognosis.
- Senescence program, particularly SASP, can both suppress tumors and support malignant progression under certain conditions.
- Single-cell and bulk transcriptomic data were integrated to study senescence-associated features in ccRCC.
- Two molecular subtypes (C1 and C2) were identified based on senescence-associated gene (SAG) expression, with C1 showing better survival outcomes.
- A risk score model using Random Survival Forest (RSF) was developed and validated across multiple cohorts.
- High-risk patients exhibited lower immune activation and a more immunosuppressive microenvironment.
- ALDH18A1 was identified as a key prognostic gene and potential therapeutic target in ccRCC.
- ALDH18A1 promotes ccRCC cell proliferation and interacts with the immune microenvironment.
- A nomogram integrating the risk score with clinical parameters showed high predictive accuracy for survival.