The incidence and antimicrobial resistance of Shigella-attributable diarrhoea in young children in low-income and middle-income countries from the multicountry Enterics for Global Health (EFGH) Shigel
4 hours ago
- #Antimicrobial Resistance
- #Diarrhoea
- #Shigella
- Shigella is a leading cause of diarrhoea and dysentery in children under 5 in LMICs, also linked to growth impairment.
- The EFGH study conducted in 7 countries (Kenya, Malawi, Mali, The Gambia, Bangladesh, Pakistan, Peru) from 2022-2024.
- Shigella was detected in 9.3% of children by culture and 20% by qPCR, with S. flexneri being the most common species.
- Adjusted incidence of Shigella-attributed diarrhoea varied by country, highest in Peru (11.7/100 child-years) and The Gambia (26.9/100 child-years).
- High antimicrobial resistance observed: ciprofloxacin (37.2%), azithromycin (22.1%), ceftriaxone (16.2%).
- Quadrivalent vaccines could cover most identified Shigella serotypes, highlighting the need for vaccine trials.