FUT1- and GAL3ST2-mediated cellular glycan remodeling broadly restricts sialic acid-dependent viral infections - PubMed
3 hours ago
- #glycosyltransferases
- #viral infection
- #antiviral strategy
- Sialic acid is a terminal glycan on mammalian cells used by many viruses for attachment or as a receptor.
- A CRISPR activation screen targeted 54 glycosyltransferases to study their effect on viral infection rates.
- Fucosyltransferase 1 (FUT1) and galactose-3-O-sulfotransferase 2 (GAL3ST2) were identified as inhibitors of a broad range of viruses when upregulated.
- FUT1 and GAL3ST2 reduce cell surface sialylation, impairing viral attachment during the initial entry process.
- Therapeutic dysregulation of FUT1 and GAL3ST2 may represent a broad-spectrum antiviral strategy.