Conserved use of tetraspanin CD9 as an entry receptor by rhabdoviruses spanning multiple genera - PubMed
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- #nitazoxanide
- #CD9
- #rhabdoviruses
- Tetraspanin CD9 identified as a conserved entry receptor for diverse rhabdoviruses across genera.
- CD9 knockout, protein, or antibody significantly reduces VHSV infection in vitro and in zebrafish.
- Human CD9 orthologue serves as a receptor for VSV, indicating cross-species functionality.
- LjCD9 mediates VHSV entry via clathrin- and caveolae-mediated endocytosis.
- Nitazoxanide (NTZ) identified as a broad-spectrum inhibitor of VHSV, SCRV, and VSV, likely by interfering with G protein-CD9 interaction.