Alterations in NK cell subsets and the regulatory role of JAB1 in nasopharyngeal carcinoma with implications for tumor immunity and biomarker development - PubMed
3 hours ago
- #NK cells
- #tumor immunity
- #JAB1 regulation
- Higher CD16+CD57+ NK cells in blood correlate with better outcomes in nasopharyngeal carcinoma (NPC) patients, while elevated CD16- NK cells indicate worse prognoses.
- JAB1 enhances NK cell cytotoxicity and plays a regulatory role in shaping the tumor immune environment.
- NK cell subsets have distinct distributions: CD16hiCD57- and CD16hiCD57+ cells are primarily in blood, whereas CD16loCD57- cells accumulate in tumors, with functional roles in both promoting and suppressing tumor growth.
- JAB1 and CD107a expression in NK cells offer superior diagnostic and prognostic value compared to traditional markers like SCC and CEA, suggesting potential for biomarker and immunotherapy target development.